Born in Buenos Aires, Insúa has more than 200 career appearances in Argentina’s Primera División and domestic cup competitions with some of the country’s most storied clubs including Boca Juniors, Newell's Old Boys, Racing Club, Vélez Sársfield, and Banfield. In Europe, Insúa passed through Spain's La Liga with Granada, Italy's Serie A with Udinese, and spent four seasons in the Greek Super League with Panathinaikos and AEK. He joined AKFC in August 2025.